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In August 2005 and January 2006 I made two trips trips to East Texas, first to help organize a show of my jazz photographs at the Longview Museum Of Fine Arts and later to attend the opening. I repeated the process again in December 2008 and June 2009, when I had another show at the museum.
When I was not attending to matters related to the shows, I drove around the countryside, my cameras loaded with black and white as well as color film. The primary purpose of the excursions in 2005 and 2006 was to find images that might be useful as chapter headings for my novel, Rose Hill. I managed to take a few photographs that may work in the book, but the vast majority didn’t relate in any way to Rose Hill. They had to
do with what I believed was a fascinating yet little explored subject: Highway 80. I took many more photographs in 2008 and 2009.
US Highway 80 was the axis of these journeys, from Terrell in the west to Waskom in the east. Jacksonville was the furthest I ventured south; Daingerfield was the most northerly. For the most part, however, I stuck pretty close to the Highway 80 corridor, venturing a few miles north or south, with multiple trips to a few towns and hamlets in and around Kilgore and Winona.
Old Highway 80, near Hallsville, 2009
These drugs work by preventing the breakdown of PDE5, which is an enzyme in penile smooth muscle which leads to better function of penile erectile tissue. The PDE5 inhibitors, although not initiating an erection, enhance erections to any given sexual stimulus.
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Several key problems still need to be addressed. For instance, it would be of great benefit to determine the structure of several PDE holoenzymes to fully understand their mechanisms of regulation. Therefore, substantial effort is being expended in this area. A concept gaining great support is the idea that different PDEs subserve different pools of cAMP and cGMP in the cell. We are only just beginning to be able to measure PDE activity in subcellular compartments of the cell in real time. This is an area that clearly needs to be developed, including identification of molecular mechanisms that provide and control PDE subcellular localization. We also need to identify good animal models that accurately reflect the regulation and roles of PDEs in human tissues as many examples now are available for different modes of regulation between mice and men. At a minimum, putative regulatory schemes identified from studies in mouse, Drosophila, or zebrafish need to be tested quickly in human tissues.
The Pittsburgh team found that the genes for the "glial cell line derived neurotrophic factor" (GDNF) and the GDNF family ligand, called neurturin, were both effective in treating erectile dysfunction in the rats. The genes were placed in a genetically engineered herpes simplex virus, which was then injected into the rats' damaged cavernous nerve.
Q. Why does injection therapy fail for some men?
In addition, always follow the directions on your prescription label carefully and ask your doctor or pharmacist to explain any part that you do not understand. Take these drugs exactly as directed. Do not take more or less or take it more often than prescribed by your doctor. Do not take these drugs more than once a day.
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Since an erection requires a precise sequence of events, ED can occur when any of the events is disrupted. The sequence includes nerve impulses in the brain, spinal column, and area around the penis, and response in muscles, fibrous tissues, veins, and arteries in and near the corpora cavernosa.
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Media file 2: Vascular disease often associated with diabetes mellitus is found in the majority of men with erectile dysfunction. In these patients, the medications they take for hypertension often exacerbate their erectile dysfunction.
"Because the herpes virus persists in the nerve cell for as long as it is alive and nerve cells typically do not reproduce, this represents the first-ever demonstration of a long-term treatment for ED that does not rely on the chronic administration of drugs that can have potentially harmful side effects," study co-leader Joseph C. Glorioso, chairman of the department of biochemistry and molecular genetics, said in a prepared statement.
"IUD" stands for "intrauterine device." An IUD is put in a woman's uterus by her doctor. It's made of flexible plastic. It isn't known exactly how IUDs prevent pregnancy. They seem to stop sperm from reaching the egg or prevent the egg from attaching to the uterus.
Can ED Be Prevented?
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